Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3.

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

Stimulatory and inhibitory co-receptors play fundamental roles in the regulation of the immune system. We describe a new mouse model of spontaneous autoimmune disease. Activation-induced cytidine deaminase-linked autoimmunity (aida) mice harbor a loss-of-function mutation in the gene encoding lymphocyte activation gene 3 (LAG-3), an inhibitory co-receptor. Although LAG-3 deficiency alone did no...

Experimental Study of the Effect of Laser-Cutting Process Parameters on Heat Distribution and Cutting Edge Quality of Steel Sheets

This study aimed to evaluate Laser-cutting process of Mild Steel St37 sheets with two different thicknesses. In order to evaluate the quality of cutting edge and the depth of the area affected by the heat, several tests were conducted to determine the effect of parameters such as Laser power, Laser beam movement speed and pressure of axillary gas on the quality of cutting edge and the depth of ...

Autoimmune Diabetes Model Lymphocytes to Transplanted Cells and in an Adjuvant Reduces the Activation of CD8 T Cutting Edge: Elimination of an Endogenous

An Instantaneous Rigid Force Model For 3-Axis Ball-End Milling Of Sculptured Surfaces

An instantaneous rigid force model for prediction of cutting forces in ball-end milling of  sculptured surfaces is presented in this paper. A commercially available geometric engine is used to represent the cutting edge, cutter and updated part geometries. The cutter used in this work is an insert type ball-end mill. Intersecting an inclined plane with the cutter ball nose generates the cutting...

Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetes.

BDC2.5/nonobese diabetic (NOD) transgenic mice express a TCR from a diabetogenic T cell clone yet do not spontaneously develop diabetes at high incidence. Evidence exists showing that in the absence of endogenous TCR alpha-chain rearrangements this transgenic mouse spontaneously develops diabetes and that CTLA-4 negatively regulates diabetes onset. This strongly suggests that onset of diabetes ...